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dc.contributor.authorAlmaliti, Jehad
dc.contributor.authorMalloy, Karla L.
dc.contributor.authorGlukhov, Evgenia
dc.contributor.authorSpadafora, Carmenza
dc.contributor.authorGutierrez, Marcelino
dc.contributor.authorGerwick, William H.
dc.date.accessioned2020-06-25T02:29:22Z
dc.date.available2020-06-25T02:29:22Z
dc.date.issued2017-05-23
dc.identifier.otherDOI: 10.1021/acs.jnatprod.7b00034
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/113
dc.descriptionHPLC. DudA family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A−D (1−4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A−D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey’s analysis, chiral-phase GCMS, and chiral-phase awalamides A−D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure−activity relationship features of these NRPS−PKS-derived metabolites and their derivatives.en_US
dc.description.abstractHPLC. DudA family of 2,2-dimethyl-3-hydroxy-7-octynoic acid (Dhoya)-containing cyclic depsipeptides, named dudawalamides A−D (1−4), was isolated from a Papua New Guinean field collection of the cyanobacterium Moorea producens using bioassay-guided and spectroscopic approaches. The planar structures of dudawalamides A−D were determined by a combination of 1D and 2D NMR experiments and MS analysis, whereas the absolute configurations were determined by X-ray crystallography, modified Marfey’s analysis, chiral-phase GCMS, and chiral-phase awalamides A−D possess a broad spectrum of antiparasitic activity with minimal mammalian cell cytotoxicity. Comparative analysis of the Dhoya-containing class of lipopeptides reveals intriguing structure−activity relationship features of these NRPS−PKS-derived metabolites and their derivatives.en_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectDudawalamidesen_US
dc.subjectAntiparasitic Cyclic Depsipeptidesen_US
dc.subjectMarine Cyanobacteriumen_US
dc.titleDudawalamides A−D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producensen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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