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dc.contributor.authorLlanes, Alejandro
dc.contributor.authorRestrepo, Carlos M.
dc.contributor.authorCaballero, Zuleima
dc.contributor.authorRajeev, Sreekumari
dc.contributor.authorKennedy, Melissa A.
dc.contributor.authorLleonart, Ricardo
dc.date.accessioned2020-06-26T23:56:31Z
dc.date.available2020-06-26T23:56:31Z
dc.date.issued2020-05-27
dc.identifier.otherdoi: 10.20944/preprints202005.0448.v1
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/124
dc.descriptionIn the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of betacoronaviruses in the aftermath of the 2002-03 severe acute respiratory syndrome (SARS) and 2012 Middle East respiratory syndrome (MERS) outbreaks. Furthermore, genome sequencing and bioinformatic analysis have had an unprecedented relevance in the battle against the 2019-20 coronavirus disease 2019 (COVID-19) pandemic, the newest and most devastating outbreak caused by a coronavirus in the history of mankind, allowing the follow up of disease spread and transmission dynamics in near real time. Here, we review how genomic information has been used to tackle outbreaks caused by emerging, highly pathogenic, betacoronavirus strains, emphasizing on SARS-CoV, MERS-CoV and SARS-CoV-2.en_US
dc.description.abstractIn the 21st century, three highly pathogenic betacoronaviruses have emerged, with an alarming rate of human morbidity and case fatality. Genomic information has been widely used to understand the pathogenesis, animal origin and mode of transmission of betacoronaviruses in the aftermath of the 2002-03 severe acute respiratory syndrome (SARS) and 2012 Middle East respiratory syndrome (MERS) outbreaks. Furthermore, genome sequencing and bioinformatic analysis have had an unprecedented relevance in the battle against the 2019-20 coronavirus disease 2019 (COVID-19) pandemic, the newest and most devastating outbreak caused by a coronavirus in the history of mankind, allowing the follow up of disease spread and transmission dynamics in near real time. Here, we review how genomic information has been used to tackle outbreaks caused by emerging, highly pathogenic, betacoronavirus strains, emphasizing on SARS-CoV, MERS-CoV and SARS-CoV-2.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbetacoronavirusesen_US
dc.subjectgenomicsen_US
dc.subjectSARS-CoVen_US
dc.subjectMERS-CoVen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCOVID-19en_US
dc.titleBetacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemicen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:edu-repo/semantics/publishedVersion


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