Browsing Artículos Científicos by Issue Date
Now showing items 41-60 of 227
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Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama
(2013-07-15)In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ... -
Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama
(2013-07-15)In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ... -
Electrical Polarization of Titanium Surfacesfor the Enhancement of Osteoblast Differentiation
(2013-08-29)Electrical stimulation has been used clinically to promote bone regeneration in cases of fractures with delayed union or nonunion, with several in vitro and in vivo reports suggesting its beneficial effects on bone formation. ... -
AFLP Polymorphisms Allow High Resolution Genetic Analysis of American Tegumentary Leishmaniasis Agents Circulating in Panama and Other Members of the Leishmania Genus
(2013-09-09)American Tegumentary Leishmaniasis is caused by parasites of the genus Leishmania, and causes significant health problems throughout the Americas. In Panama, Leishmania parasites are endemic, causing thousands of new cases ... -
Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants
(2013-09-16)Fungal endophytes – fungi that grow within plant tissues without causing immediate signs of disease – are abundant and diverse producers of bioactive secondary metabolites. Endophytes associated with leaves of tropical ... -
Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants
(2013-09-16)Fungal endophytes – fungi that grow within plant tissues without causing immediate signs of disease – are abundant and diverse producers of bioactive secondary metabolites. Endophytes associated with leaves of tropical ... -
Copper interactions with DNA of chromatin and its rolein neurodegenerative disorders.
(2013-10-01)In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm ... -
Copper interactions with DNA of chromatin and its role in neurodegenerative disorders
(2013-10-01)In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm ... -
High clustering rates of multidrug-resistant Mycobacterium tuberculosisgenotypes in Panama
(2013-12-01)Background: Tuberculosis continues to be one of the leading causes of death worldwide and in the American region. Although multidrug-resistant tuberculosis (MDR-TB) remains a threat to TB control in Panama, few studies ... -
Mosquito-Host Interactions during and after an Outbreak of Equine Viral Encephalitis in Eastern Panama
(2013-12-10)Mosquito blood meals provide information about the feeding habits and host preference of potential arthropod-borne disease vectors. Although mosquito-borne diseases are ubiquitous in the Neotropics, few studies in this ... -
A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages
(2013-12-16)Several diterpenoids isolated from terrestrial and marine environments have been identified as important anti-inflammatory agents. Although considerable progress has been made in the area of anti-inflammatory treatment, ... -
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
(2014-01-01)α-Synuclein aggregation is one of the major etiological factors implicated in Parkinson's disease (PD). The prevention of ggregation of α-synuclein is a potential therapeutic intervention for preventing PD. The discovery ... -
The effects of impaired cerebral circulation on Alzheimer's disease pathology: evidence from animal studies.
(2014-01-01)Persistent systemic hypoxia, a direct consequence of alterations in vascular function, can compromise the brain by increasing the risk of developing dementias such as Alzheimer’s disease (AD). Vascular contributions to ... -
Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil
(2014-01-13)Plinia cerrocampanensis is an endemic plant of Panama. The leaf essential oil of this plant has shown antibacterial activity. However, anti-malarial activity and chemical profiling by HS-SPME-GC-MS of this essential oil ... -
Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil
(2014-01-13)Background Plinia cerrocampanensis is an endemic plant of Panama. The leaf essential oil of this plant has shown antibacterial activity. However, anti-malarial activity and chemical profiling by HS-SPME-GC-MS of this ... -
Sloth Hair as a Novel Source of Fungi with Potent AntiParasitic, Anti-Cancer and Anti-Bacterial Bioactivity
(2014-01-15)The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial ... -
Sloth Hair as a Novel Source of Fungi with Potent AntiParasitic, Anti-Cancer and Anti-Bacterial Bioactivity
(2014-01-15)The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial ... -
The lipid content and fatty acid composition of four eastern central Pacific native fish species
(2014-02-01)Fish is an important source of nutritious n-3 fatty acids, which are necessary for the prevention of cardiovascular and neurological diseases. The lipid content and fatty acid composition of economically important fishes ... -
Malarial hemozoin: From target to tool
(2014-02-17)Malaria is an extremely devastating disease that continues to affect millions of people each year. A distinctive attribute of malaria infected red blood cells is the presence of malarial pigment or so-called hemozoin. ... -
Malarial hemozoin: From target to tool
(2014-02-17)Malaria is an extremely devastating disease that continues to affect millions of people each year. A distinctive attribute of malaria infected red blood cells is the presence of malarial pigment or the so-called hemozoin. ...