Browsing Artículos Científicos by Author "Vasquez, Velmarini"
Now showing items 1-8 of 8
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Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-09-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson’s disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2017-01-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson’s Disease
Vasquez, Velmarini; Mitra, Joy; Perry, George; Rao, KS Jagannatha; Hegde, Muralidhar L. (2018-11-08)Altered expression of α-synuclein is linked to Parkinson’s disease (PD). A major challenge to explore how the increased α-synuclein affect neurotoxicity is the lack of a suitable human neuronal cell model that mimics this ... -
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Liachko, Nicole F; Wang, Haibo; Vasquez, Velmarini; Gao, Junling; Pandey, Arvind; Taylor, J Paul; Kraemer, Brian C; Wu, Ping; Boldogh, Istvan; Garruto, Ralph M; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-03-05)Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The ... -
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
Vasquez, Velmarini; Mitra, Joy; Wang, Haibo; Hegde, Pavana M; Rao, KS Jagannatha; Hegde, Muralidhar L (2020-02-01)α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ... -
Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential
Mitra, Joy; Vasquez, Velmarini; Hegde, Pavana M; Boldogh, Istvan; Mitra, Sankar; Kent, Thomas A; Rao, Kosagi S; L Hegde, Muralidhar (2014-12-31)Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as ... -
Revisiting metal toxicity in neurodegenerative diseases and stroke: Therapeutic potential.
Mitra, Joy; Vasquez, Velmarini; Hegde, Pavana M.; Boldogh, Istvan; Mitra, Sankar; Kent, Thomas A.; Rao, KS Jagannatha; Hegde, Muralidhar L (2015-01-23)Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as ... -
α-Synuclein misfolding versus aggregation relevance to Parkinson’s disease: Critical assessment and modeling
Berrocal, Ruben; Vasquez, Velmarini; Rao Krs, Sambasiva; Gadad, Bharathi S; Rao, KS Jagannatha (2015-06-01)α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in Parkinson’s disease (PD). The aggregation of α-synuclein isbelieved to be a critical event in the isease process. ...