Browsing by Author "Hegde, Muralidhar L"
Now showing items 1-9 of 9
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Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, Johant; Kumar D., Jagadeesh; Hegde, Muralidhar L; Rao, KS Jagannatha (2019-11-07)Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, ... -
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-09-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson’s disease
Vasquez, Velmarini; Mitra, Joy; Hegde, Pavana M; Pandey, Arvind; Sengupta, Shiladitya; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2017-01-01)Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ... -
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Liachko, Nicole F; Wang, Haibo; Vasquez, Velmarini; Gao, Junling; Pandey, Arvind; Taylor, J Paul; Kraemer, Brian C; Wu, Ping; Boldogh, Istvan; Garruto, Ralph M; Mitra, Sankar; Rao, KS Jagannatha; Hegde, Muralidhar L (2019-03-05)Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The ... -
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
Vasquez, Velmarini; Mitra, Joy; Wang, Haibo; Hegde, Pavana M; Rao, KS Jagannatha; Hegde, Muralidhar L (2020-02-01)α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ... -
New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Wang, Haibo; Boldogh, Istvan; Rao, Kosagi Sharaf; Mitra, Sankar; Hegde, Muralidhar L (2014-07-17)The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, e.g., oxidative ... -
New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Wang, Haibo; Boldogh, Istvan; Rao, KS Jagannatha; Mitra, Sankar; Hegde, Muralidhar L (2014-07-17)The primary cause (s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, eg, oxidative ... -
Revisiting metal toxicity in neurodegenerative diseases and stroke: Therapeutic potential.
Mitra, Joy; Vasquez, Velmarini; Hegde, Pavana M.; Boldogh, Istvan; Mitra, Sankar; Kent, Thomas A.; Rao, KS Jagannatha; Hegde, Muralidhar L (2015-01-23)Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as ... -
TDP-43/FUS in motor neuron disease: complexity and challenges
Guerrero, Erika N; Wang, Haibo; Mitra, Joy; Hegde, Pavana M; Stowell, Sara E; Liachko, Nicole F; Kraemer, Brian C; Garruto, Ralph M; Rao, KS Jagannatha; Hegde, Muralidhar L (2016-10-01)Amyotrophic lateral sclerosis (ALS), a common motor neuron disease affecting two per 100,000 people worldwide, encompasses at least five distinct pathological subtypes, including, ALS-SOD1, ALS-C9orf72, ALS-TDP-43, ALS-FUS ...