Browsing by Author "Lakey-Beitia, Johant"
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Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer’s drug discovery
Lakey-Beitia, Johant; Doens, Deborah; Kumar, D Jagadeesh; Murillo, Enrique; L Fernandez, Patricia; Rao, KS Jagannatha; Durant-Archibold, Armando A (2017-05-15)Alzheimer’s disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for ... -
Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer's Disease
Lakey-Beitia, Johant; González, Yisett; Doens, Deborah; Stephens, David E; Santamaría, Ricardo; Murillo, Enrique; Gutiérrez, Marcelino; L Fernández, Patricia; Rao, KS Jagannatha; Larionov, Oleg V; Durant-Archibold, Armando A (2017-01-01)Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting the elderly population worldwide. Brain inflammation plays a key role in the progression of AD. Deposition of senile plaques in the brain ... -
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
Lakey-Beitia, Johant; Kumar D., Jagadeesh; Hegde, Muralidhar L; Rao, KS Jagannatha (2019-11-07)Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, ...