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dc.contributor.authorRodriguez, Candelario
dc.contributor.authorIbañez, Roberto
dc.contributor.authorNg, Michelle
dc.contributor.authorSpadafora, Carmenza
dc.contributor.authorDurant-Archibold, Armando A.
dc.contributor.authorGutierrez, Marcelino
dc.date.accessioned2020-07-01T22:01:13Z
dc.date.available2020-07-01T22:01:13Z
dc.date.issued2020-02-13
dc.identifier.other/doi.org/10.1016/j.toxicon.2020.02.009
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/150
dc.descriptionAmerican trypanosomiasis is a parasitic neglected disease, responsible for the death of approximately 10,000 people every year. Amphibians are recognized for producing in their cutaneous glands substances with pharmacological potential against a variety of pathologies. Here we investigated the antiprotozoal activity against Trypanosoma cruzi of bufadienolides isolated from the parotoid glands secretions of the toad Rhinella centralis from Panama. NMR and mass spectrometry analysis led to the identification of the active compound 19-hydroxybufalin, for which its antitrypanosomal activity and occurrence in the genus Rhinella are reported for the first time. This compound showed low cytotoxicity and significant selectivity which confers to it a potential role for the treatment of Chagas diseaseen_US
dc.description.abstractAmerican trypanosomiasis is a parasitic neglected disease, responsible for the death of approximately 10,000 people every year. Amphibians are recognized for producing in their cutaneous glands substances with pharmacological potential against a variety of pathologies. Here we investigated the antiprotozoal activity against Trypanosoma cruzi of bufadienolides isolated from the parotoid glands secretions of the toad Rhinella centralis from Panama. NMR and mass spectrometry analysis led to the identification of the active compound 19-hydroxybufalin, for which its antitrypanosomal activity and occurrence in the genus Rhinella are reported for the first time. This compound showed low cytotoxicity and significant selectivity which confers to it a potential role for the treatment of Chagas diseaseen_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectRhinella centralisen_US
dc.subjectToad Bufonidaeen_US
dc.subjectParotoid glanden_US
dc.subjectgland secretionen_US
dc.subjectBufadienolide Antitrypanosomalen_US
dc.subjectactivity Trypanosoma cruzien_US
dc.title19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzien_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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