Investigación: Recent submissions
Now showing items 201-220 of 227
-
Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama
(2013-07-15)In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ... -
Automated Synchronization of P. falciparum using a Temperature Cycling Incubator
(2011-04)As malaria keeps affecting millions of lives every year, research based in culture of Plasmodium falciparum in vitro needs to be efficient and accurate. The development of better techniques and methodologies for the growth ... -
Revisión de Modelos Hiperelásticos utilizados en Tejidos
(2018-02-04)This work is related to the hyperelastic models most used in soft tissue. The importance of obtaining accurate mechanical properties of tissues are of great interest for various medical applications, for example: in treatment ... -
Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum
(2010-06-17)Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are ... -
Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi
(2011-03-30)Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic ... -
Cytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera. EmilyCytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera.
(2011-04-13)A family of cancer cell cytotoxic cyclodepsipeptides, veraguamides A-C( 1-3) and H-L( 4-8), were isolated from a collection of cf. Oscillatoria margaritifera obtained from the Coiba National Park, Panama, as part of the ... -
In vitro and in vivo experimental models for drug screening and development for Chagas disease
(2010-03-02)Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control ... -
Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means
(2023-03-02)Unlike other Plasmodium species, P. falciparum can be cultured in the lab, which facilitates its study 1. While the parasitemia achieved can reach the ≈40% limit, the investigator usually keeps the percentage at around ... -
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
(2012-09-18)Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), ... -
Thermo-Energetic Study in Blood Infected with Plasmodium falciparum radiated at 2.45GHz
(IEEE, 2019-11-25)Malaria is a disease that affects the world, caused by the parasite Plasmodium which resistance is emerging to medications that usually control it. Therefore, it is essential to seek alternative treatments like this one, ... -
Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice
(2020-03-09)Plasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasite s resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments ... -
Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa
(2019-01-01)Fractionation of the ethyl acetate extract of the bacterium Pseudomonas aeruginosa led to the isolation of five compounds, cyclo –(L-Phe-L-Pro) (1), 3-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2.4-dione (2), ... -
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
(2019-03-25)Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has ... -
Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién
(2019-04-02)Cocos nucifera (C. nucifera) (the coconut palm tree) has been traditionally used to fight a number of human diseases, but only a few studies have tested its components against parasites such as those that cause malaria. ... -
Extracellular Vesicles Could Carry an Evolutionary Footprint in Interkingdom Communication
(Frontiers, 2020-03-03)Extracellular vesicles (EVs) are minute particles secreted by the cells of living organisms. Although the functional role of EVs is not yet clear, recent work has highlighted their role in intercellular communication. Here, ... -
Recommendations of generic names in Diaporthales competing for protection or use.
(2015-06-04)In advancing to one name for fungi, this paper treats generic names competing for use in the order Diaporthales (Ascomycota, Sordariomycetes) and makes a recommendation for the use or protection of one generic name among ... -
New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
(biomolecules, 2014-07-17)The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, e.g., oxidative ... -
Utilidad de la escala de depresión geriátrica en adultos mayores atendidos en el servicio de geriatría de la caja de seguro social
(Revista Médico Científica, 2017-11-23)INTRODUCCIÓN. La depresión en pacientes geriátricos consiste de síntomas y características clínicas específicas que representan una condición grave que predispone a alteraciones en la funcionalidad de esta población. La ... -
Mycobacterial Lipids Induce Calcium Mobilization and Degranulation of Mast Cells
(American Journal of Respiratory and Critical Care Medicine, 2018-09-15)Tuberculosis (TB) remains the leading cause of death from a single infectious agent, followed by HIV/AIDS (1). Emerging countries, such as Panama, have not been able to curb TB infection rates. The development of novel ... -
HS-C reactive protein and red blood cell distribution width as effective markers for hypertension
(International Journal of Advances in Medicine, 2016-04-06)Background: Hypertension or elevated blood pressure is one of the leading causes of morbidity and mortality. HsCRP, which is a known marker for CVD, is also one of the predictive markers of inflammation processes which ...