Investigación: Recent submissions

Now showing items 81-100 of 227

    • In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics. 

      Berrocal, Ruben; Vasudevaraju, Padmaraju; Indi, Shantinath Satappa; Rao, Krothapalli Raja Surya Sambasiva; Rao, KS Jagannatha (2014-01-01)
      α-Synuclein aggregation is one of the major etiological factors implicated in Parkinson's disease (PD). The prevention of ggregation of α-synuclein is a potential therapeutic intervention for preventing PD. The discovery ...

    • The effects of impaired cerebral circulation on Alzheimer's disease pathology: evidence from animal studies. 

      Villarreal, Alcibiades E.; Barron, Rachel; Rao, KS Jagannatha; Britton, Gabrielle B. (2014-01-01)
      Persistent systemic hypoxia, a direct consequence of alterations in vascular function, can compromise the brain by increasing the risk of developing dementias such as Alzheimer’s disease (AD). Vascular contributions to ...

    • Vacuolar Targeting of Cry1Ac and its Effects on Expression and Stability in Tobacco. 

      Singh, Vivek Kumar; Gothandapani, Sellamuthu; Phanindra, Mullapudi Lakshmi Venkata; Nain, Vikrant; Sreevathsa, Rohini; Rao, KS Jagannatha; Kumar, Polumetla Ananda (2014-07-01)
      Increasing heterologous expression of delta endotoxins of Bacillus thuringiensis in transgenic plants is being actively pursued as a means to increase their efficacy and to delay insect resistance. To examine if vacuoles ...

    • Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts 

      Ramesh, BN; Girish, TK; Raghavendra, RH; Akhilender Naidu, K; Rao, UJS Prasada; Rao, KS Jagannatha (2014-04-01)
      Background: Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Caesalpinia crista and Centella asiatica leaf extracts are ...

    • Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015 

      Wang, Haidong; Wolock, Tim M; Carter, Austin; Nguyen, Grant; Kyu, Hmwe Hmwe; Gakidou, Emmanuela; Hay, Simon I; Mills, Edward J; Trickey, Adam; Msemburi, William; Coates, Matthew M; Mooney, Meghan D; Fraser, Maya S; Sligar, Amber; Salomon, Joshua; Larson, Heidi J; Friedman, Joseph; Alemu Abajobir, Amanuel; Hassen Abate, Kalkidan; Abbas, Kaja M; Abd El Razek, Mohamed Magdy; Abd-Allah, Foad; Abdulle, Abdishakur M; Ferede Abera, Semaw; Abubakar, Ibrahim; Abu-Raddad, Laith J; Abu-Rmeileh, Niveen ME; Yitayih Abyu, Gebre; Olupelumi Adebiyi, Akindele; Akinkunmi Adedeji, Isaac; Lukman Adelekan, Ademola; Adofo, Koranteng; Kouablan Adou, Arsène; N Ajala, Oluremi; Akinyemiju, Tomi F; Akseer, Nadia; Hasan Al Lami, Faris; Al-Aly, Ziyad; Alam, Khurshid; Alam, Noore KM; Alasfoor, Deena; Aldhahri, Saleh Fahed S; William Aldridge, Robert; Alegretti, Miguel Angel; Aleman, Alicia V; Aderaw Alemu, Zewdie; Alfonso-Cristancho, Rafael; Ali, Raghib; Alkerwi, Ala'a; Alla, François; Mohammad, Rajaa; Al-Raddadi, Salem; Alsharif, Ubai; Alvarez, Elena; Alvis-Guzman, Nelson; Amare, Azmeraw T; Amberbir, Alemayehu; Kofi Amegah, Adeladza; Ammar, Walid; Amrock, Stephen Marc; T Antonio, Carl Abelardo; Anwari, Palwasha; Ärnlöv, Johan; Artaman, Al; Asayesh, Hamid; Asghar, Rana Jawad; Assadi, Reza; Atique, Suleman; Atkins, Lydia S; Arthur Avokpaho, Euripide Frinel G; Awasthi, Ashish; Ayala Quintanilla, Beatriz Paulina; Bacha, Umar; Badawi, Alaa; Barac, Aleksandra; Bärnighausen, Till; Basu, Arindam; Assefa Bayou, Tigist; Tebekaw Bayou, Yibeltal; Bazargan-Hejazi, Shahrzad; Beardsley, Justin; Bedi, Neeraj; Bennett, Derrick A; Bensenor, Isabela M; Betsu, Balem Demtsu; Beyene, Addisu Shunu; Bhatia, Eesh; Bhutta, Zulfiqar A; Biadgilign, Sibhatu; Bikbov, Boris; Mentes Birlik, Sait; Bisanzio, Donal; Brainin, Michael; Brazinova, Alexandra; Breitborde, Nicholas JK; Brown, Alexandria; Burch, Michael; Butt, Zahid A; Campuzano, Julio Cesar; Cárdenas, Rosario; Carrero, Juan Jesus; Castañeda-Orjuela, Carlos A; Castillo Rivas, Jacqueline; Catalá-López, Ferrán; Chang, Hsing-Yi; Chang, Jung-chen; Chavan, Laxmikant; Chen, Wanqing; Chiang, Peggy Pei-Chia; Chibalabala, Mirriam; Chisumpa, Vesper Hichilombwe; Choi, Jee-Young Jasmine; Christopher, Devasahayam Jesudas; Ciobanu, Liliana G; Cooper, Cyrus; Dahiru, Tukur; Abrha Damtew, Solomon; Dandona, Lalit; Dandona, Rakhi; das Neves, José; de Jager, Pieter; De Leo, Diego; Degenhardt, Louisa; Dellavalle, Robert P; Deribe, Kebede; Deribew, Amare; Des Jarlais, Don C; Dharmaratne, Samath D; Ding, Eric L; Doshi, Pratik Pinal; Doyle, Kerrie E; Driscoll, Tim R; Dubey, Manisha; Elshrek, Yousef Mohamed; Elyazar, Iqbal; Endries, Aman Yesuf; Petrovich Ermakov, Sergey; Eshrati, Babak; Esteghamati, Alireza; DA Faghmous, Imad; Faro, Andre; Farvid, Maryam S; Farzadfar, Farshad; Fereshtehnejad, Seyed-Mohammad; Fernandes, Joao C; Fischer, Florian; Anderson Fitchett, Joseph Robert; Foigt, Nataliya; Fullman, Nancy; Fürst, Thomas (2016-08-01)
      Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and ...

    • New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases 

      Mitra, Joy; Guerrero, Erika N; Hegde, Pavana M; Wang, Haibo; Boldogh, Istvan; Rao, KS Jagannatha; Mitra, Sankar; Hegde, Muralidhar L (2014-07-17)
      The primary cause (s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, eg, oxidative ...

    • A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods 

      Madrigal, Marialaura; Rao, KS Jagannatha; Riordan, Neil H (2014-10-11)
      The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the ...

    • American trypanosomiasis, or Chagas disease, in Panama: a chronological synopsis of ecological and epidemiological research 

      Rodriguez, Indra G.; Loaiza, Jose R. (2017-10-10)
      American trypanosomiasis, or Chagas disease, is a growing public health problem in Panama, and further forest degradation due to human population growth is expected to worsen the situation. Most people infected with the ...

    • Maternal invasion history of Aedes aegypti and Aedes albopictus into the Isthmus of Panama: Implications for the control of emergent viral disease agents 

      Eskildsen, Gilberto A.; Loaiza, Jose R.; Smith, Octavio; Miller, Matthew J.; Bennet, Kelly L.; McMillan, W. Owen; Rovira, Jose R. (2018-03-26)
      Despite an increase in dengue outbreaks and the arrival of chikungunya and Zika disease in Panama, studies on the demographic history of the invasive Aedes mosquitoes that are the principle vectors of these diseases are ...

    • Socioeconomic and demographic predictors of resident knowledge, attitude, and practice regarding arthropod-borne viruses in Panama 

      Whiteman, Ari; Mejia, A.; Hernandez, I.; Loaiza, Jose R. (2018-09-18)
      Background: We sought to identify if socioeconomic and demographic factors play a role in resident knowledge, attitude, and practice regarding Dengue, Chikungunya, and Zika in order to inform effective management procedures ...

    • A systematic account of the genus Plagiostoma (Gnomoniaceae, Diaporthales) based on morphology, host-associations, and a four-gene phylogeny 

      Mejía, L.C.; Castlebury, L.A.; Rossman, A.Y.; Sogonov, M.V.; WhiteJr., J.F. (2014-05-27)
      Members of the genus Plagiostoma inhabit leaves, stems, twigs, and branches of woody and herbaceous plants predominantly in the temperate Northern Hemisphere. An account of all known species of Plagiostoma including ...

    • Erratum: Correction to Lancet HIV ((2016) 3 (e361–87)(S235230181630087X)(10.1016/S2352-3018 (16) 30087-X) 

      Wang, Haidong; M Wolock, Tim; Carter, Austin; Nguyen, Grant; Kyu, Hmwe Hmwe; Gakidou, Emmanuela; I Hay, Simon; J Mills, Edward; Trickey, Adam; Msemburi, William; M Coates, Matthew; D Mooney, Meghan; S Fraser, Maya; Sligar, Amber; Salomon, Joshua; J Larson, Heidi; Friedman, Joseph; Alemu Abajobir, Amanuel; Hassen Abate, Kalkidan; M Abbas, Kaja; Abd El Razek, Mohamed Magdy; Abd-Allah, Foad; Abdulle, Abdishakur; Ferede Abera, Semaw; Abubakar, Ibrahim; Abu-Raddad, Laith J; Abu-Rmeileh, Niveen ME; Yitayih Abyu, Gebre; Olupelumi Adebiyi, Akindele; Akinkunmi Adedeji, Isaac; Lukman Adelekan, Ademola; Adofo, Koranteng; N Ajala, Oluremi; Akinyemiju, Tomi F; Akseer, Nadia; Hasan Al Lami, Faris; Al-Aly, Ziyad; Alam, Khurshid; KM Alam, Noore; Alasfoor, Deena; S Aldhahri, Saleh Fahed; William Aldridge, Robert; Alegretti, Miguel Angel; V Aleman, Alicia; Alemu, Zewdie Aderaw; Alfonso-Cristancho, Rafael; Ali, Raghib; Alkerwi, Ala'a; Mohammad, Rajaa; Al-Raddadi, Salem; Alsharif, Ubai; Alvarez, Elena; Alvis-Guzman, Nelson; T Amare, Azmeraw; Amberbir, Alemayehu; Kofi Amegah, Adeladza; Ammar, Walid; Marc Amrock, Stephen; T Antonio, Carl Abelardo; Anwari, Palwasha; Johan, Ã; Artaman, Al; Asayesh, Hamid; Jawad Asghar, Rana; Assadi, Reza; Atique, Suleman; S Atkins, Lydia; Arthur Avokpaho, Euripide Frinel G; Awasthi, Ashish; Ayala Quintanilla, Beatriz Paulina; Bacha, Umar; Badawi, Alaa; Barac, Aleksandra; Till, BÃ; Basu, Arindam; Assefa Bayou, Tigist; Tebekaw Bayou, Yibeltal; Bazargan-Hejazi, Shahrzad; Beardsley, Justin; Bedi, Neeraj; A Bennett, Derrick; M Bensenor, Isabela; Demtsu Betsu, Balem; Shunu Beyene, Addisu; Bhatia, Eesh; A Bhutta, Zulfiqar; Biadgilign, Sibhatu; Bikbov, Boris; Birlik, Sait Mentes; Bisanzio, Donal; Brainin, Michael; Brazinova, Alexandra; JK Breitborde, Nicholas; Brown, Alexandria; Burch, Michael; A Butt, Zahid; Campuzano, Julio Cesar; Rosario, CÃ; Carrero, Juan Jesus; Castañeda-Orjuela, Carlos A; Castillo Rivas, Jacqueline; Yi Chang, Hsing; chen Chang, Jung; Chavan, Laxmikant; Chen, Wanqing; Chia Chiang, Peggy Pei; Chibalabala, Mirriam; Hichilombwe Chisumpa, Vesper; Jasmine Choi, Jee Young; Jesudas Christopher, Devasahayam; Ciobanu, Liliana G; Cooper, Cyrus; Dahiru, Tukur; Abreha Damtew, Solomon; Dandona, Lalit; Dandona, Rakhi; de Jager, Pieter; De Leo, Diego; Degenhardt, Louisa; Dellavalle, Robert P; Deribe, Kebede; Deribew, Amare; Jarlais, Don Des; Dharmaratne, Samath D; L Ding, Eric; Pinal Doshi, Pratik; R Driscoll, Tim; Dubey, Manisha; Elshrek, Yousef Mohamed; Elyazar, Iqbal; Yesuf Endries, Aman; Petrovich Ermakov, Sergey; Eshrati, Babak; Esteghamati, Alireza; Faghmous, Imad DA; Faro, Andre; S Farvid, Maryam; Farzadfar, Farshad; Fereshtehnejad, Seyed Mohammad; Fernandes, Joao C; Fischer, Florian; Ander Fitchett, Joseph Robert; Foigt, Nataliya; Fullman, Nancy; Fürst, Thomas; Gebre, Teshome; Tesfay Gebremedhin, Amanuel; Aregay Gebru, Alemseged; Geleijnse, Johanna M; Gessner, Bradford D (2016-09-01)
      GBD 2015 HIV Collaborators. Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015. Lancet HIV 2016; 3: e361–87—In this Article, Kerrie ...

    • Pervasive effects of a dominant foliar endophytic fungus on host genetic and phenotypic expression in a tropical tree 

      Mejía, Luis C.; Herre, Edward A.; Sparks, Jed P.; Winter, Klaus; García, Milton N.; Van Bael, Sunshine A.; Stitt, Joseph; Shi, Zi; Zhang, Yufan; Guiltinan, Mark J.; Maximova, Siela N. (2014-09-12)
      It is increasingly recognized that macro-organisms (corals, insects, plants, vertebrates) consist of both host tissues and multiple microbial symbionts that play essential roles in their host’s ecological and evolutionary ...

    • ECOLOGICAL IMPLICATIONS OF ANTI-PATHOGEN EFFECTS OF TROPICAL FUNGAL ENDOPHYTES AND MYCORRHIZAE 

      HERRE, EDWARD ALLEN; MEJIA, LUIS C.; KYLLO, DAMOND A.; ROJAS, ENITH; MAYNARD, ZULEYKA; BUTLER, ANDRE; VAN BAEL, SUNSHINE A. (2007-03-01)
      We discuss studies of foliar endophytic fungi (FEE) and arbuscular mycorrhizal fungi (AMF) associated with Theobroma cacao in Panama. Direct, experimentally controlled comparisons of endophyte free (E—) and endophyte ...

    • Molecular validation of anthropophilic Phlebotominae sandflies (Diptera: Psychodidae) in Central Panama 

      Dutar, Larissa; Loaiza, Jose R. (2019-08-15)
      Six Phlebotominae sand fly species are incriminated as biological vectors of human pathogens in Panama, but molecular corroboration is still needed. We aim at confirming the identity of Phlebotominae species documented as ...

    • The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama 

      Bennett, Kelly L.; McMillan, W. Owen; Loaiza, Jose R. (2019-01-01)
      Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on vector population fitness and persistence. However, the extent that vector populations are adapted to ...

    • Mitogenomics of Central American weakly-electric fishes 

      Aguilar, Celestino; Miller, Matthew J.; Loaiza, Jose R.; Krahe, Rüdiger; De León, Luis F. (2019-02-20)
      Electric fishes are a diverse group of freshwater organisms with the ability to generate electric organ discharges (EODs) that are used for communication and electrolocation. This group (ca. 200 species) has originated in ...

    • Mycobacterium bovis in Panama, 2013 

      Acosta, Fermín; Chernyaeva, Ekatherina; Mendoza, Libardo; Sambrano, Dilcia; Correa, Ricardo; Rotkevich, Mikhail; Tarté, Miroslava; Hernández, Humberto; Velazco, Bredio; de Escobar, Cecilia; H. de Waard, Jacobus; Goodridge, Amador (2015-06-01)
      Panama remains free of zoonotic tuberculosis caused by Mycobacterium bovis. However, DNA fingerprinting of 7 M. bovis isolates from a 2013 bovine tuberculosis outbreak indicated minimal homology with strains previously ...

    • 19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi 

      Rodriguez, Candelario; Ibañez, Roberto; Ng, Michelle; Spadafora, Carmenza; Durant-Archibold, Armando A.; Gutierrez, Marcelino (2020-02-13)
      American trypanosomiasis is a parasitic neglected disease, responsible for the death of approximately 10,000 people every year. Amphibians are recognized for producing in their cutaneous glands substances with pharmacological ...

    • Diverse novel phleboviruses in sandflies from the Panama Canal area, Central Panama 

      Marklewitz, Marco; Dutari, Larissa C.; Paraskevopoulou, Sofia; Loaiza, Jose R.; Junglen, Sandra (2019-05-03)
      The genus Phlebovirus (order Bunyavirales, family Phenuiviridae) comprises 57 viruses that are grouped into nine speciescomplexes. Sandfly-transmitted phleboviruses are found in Europe, Africa and the Americas and are ...