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Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa
| dc.contributor.author | Martínez-Luis, Sergio | |
| dc.contributor.author | Cherigo, Lilia | |
| dc.contributor.author | Spadafora, Carmenza | |
| dc.contributor.author | Gutiérrez, Marcelino | |
| dc.date.accessioned | 2020-05-27T23:21:01Z | |
| dc.date.available | 2020-05-27T23:21:01Z | |
| dc.date.issued | 2019-01-01 | |
| dc.identifier.other | https://doi.org/10.1177/1934578X1901400109 | |
| dc.identifier.uri | http://repositorio-indicasat.org.pa/handle/123456789/32 | |
| dc.description | Fractionation of the ethyl acetate extract of the bacterium Pseudomonas aeruginosa led to the isolation of five compounds, cyclo –(L-Phe-L-Pro) (1), 3-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2.4-dione (2), 2-heptyl-4-hydroxyquinoline (3), 2-nonyl-4-hydroxyquinoline (4), and 1-phenazinecarboxylic acid (5). The structures of compounds 1-5 were established by spectroscopic analyses. Compounds 2 4 produced inhibition on the growth of Plasmodium falciparum, with IC50 values of 3.47, 2.57 and 2.79 μg/mL, respectively. Compounds 3-4 had activity against Trypanosoma cruzi, with IC50 values of 3.66 and 3.99 μg/mL. Finally, all compounds were found inactive when tested against Leishmania donovani at 10 μg/mL. | en_US |
| dc.description.abstract | Fractionation of the ethyl acetate extract of the bacterium Pseudomonas aeruginosa led to the isolation of five compounds, cyclo –(L-Phe-L-Pro) (1), 3-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2.4-dione (2), 2-heptyl-4-hydroxyquinoline (3), 2-nonyl-4-hydroxyquinoline (4), and 1-phenazinecarboxylic acid (5). The structures of compounds 1-5 were established by spectroscopic analyses. Compounds 2 4 produced inhibition on the growth of Plasmodium falciparum, with IC50 values of 3.47, 2.57 and 2.79 μg/mL, respectively. Compounds 3-4 had activity against Trypanosoma cruzi, with IC50 values of 3.66 and 3.99 μg/mL. Finally, all compounds were found inactive when tested against Leishmania donovani at 10 μg/mL. | en_US |
| dc.language.iso | en | en_US |
| dc.subject | Pseudomonas aeruginosa | en_US |
| dc.subject | Trypanosoma cruzi | en_US |
| dc.subject | malaria | en_US |
| dc.subject | Chagas disease | en_US |
| dc.title | Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa | en_US |
| dc.type | Article | en_US |
