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Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
(2017-09-18)
Ten antifouling 14-membered resorcylic acid lactones 1–10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation conditions ...
Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice
(2016-11-01)
Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. Objective—To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. ...
Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice
(2016-11-08)
Context—Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce.
Objective—To identify novel cyanobacterial compounds that exhibit CNS psychoactive ...
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
(2019-03-25)
Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has ...
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
(2012-09-18)
Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), ...
Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means
(2013-02-20)
Unlike other Plasmodium species, P. falciparum can be cultured in the lab, which facilitates its study 1 . While the parasitemia achieved can reach the ≈40% limit, the investigator usually keeps the percentage at around ...
Coibacins A D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins
(2012-08-03)
Four unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, ...
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
(2012-09-18)
Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), ...
Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil
(2014-01-13)
Background Plinia cerrocampanensis is an endemic plant of Panama. The leaf essential oil of this plant has shown antibacterial activity. However, anti-malarial activity and chemical profiling by HS-SPME-GC-MS of this ...
Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
(2017-09-18)
Ten antifouling 14-membered resorcylic acid lactones 1–10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation conditions ...