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Coibacins A D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins

dc.contributor.authorBalunas, Marcy J.
dc.contributor.authorGrosso, Manuel F.
dc.contributor.authorVilla, Francisco A.
dc.contributor.authorEngene, Niclas
dc.contributor.authorMcPhail, Kerry L.
dc.contributor.authorTidgewell, Kevin
dc.contributor.authorPineda, Laura M.
dc.contributor.authorGerwick, Lena
dc.contributor.authorSpadafora, Carmenza
dc.contributor.authorKyle, Dennis E.
dc.contributor.authorGerwick, William H.
dc.date.accessioned2020-06-15T22:36:12Z
dc.date.available2020-06-15T22:36:12Z
dc.date.issued2012-08-03
dc.identifier.otherhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449157/
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/65
dc.descriptionFour unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the “beta branch” forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.en_US
dc.description.abstractFour unsaturated polyketide lactone derivatives, coibacins A-D, were isolated from a Panamanian marine cyanobacterium, cf. Oscillatoria sp. The two different types of termini observed in these co-occurring metabolites, either a methyl cyclopropyl ring as seen in curacin A or a methyl vinyl chloride similar to that observed in the jamaicamides, suggest an intriguing flexibility in the “beta branch” forming biosynthetic process. The coibacins possess selective antileishmanial activity as well as potent anti-inflammatory activity.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAntileishmanial Marineen_US
dc.subjectCyanobacterial Polyketidesen_US
dc.subjectwith Intriguingen_US
dc.subjectBiosynthetic Originsen_US
dc.titleCoibacins A D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Originsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:eu-repo/semantics/publishedVersion


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