| dc.contributor.author | Torres-Mendoza, Daniel | |
| dc.contributor.author | Coronado, Lorena M. | |
| dc.contributor.author | Pineda, Laura M. | |
| dc.contributor.author | Guzmán, Héctor M. | |
| dc.contributor.author | Dorrestein, Pieter C. | |
| dc.contributor.author | Spadafora, Carmenza | |
| dc.contributor.author | Gutiérrez, Marcelino | |
| dc.date.accessioned | 2020-06-18T04:29:47Z | |
| dc.date.available | 2020-06-18T04:29:47Z | |
| dc.date.issued | 2018-08-29 | |
| dc.identifier.other | doi:10.3390/molecules23092179 | |
| dc.identifier.uri | http://repositorio-indicasat.org.pa/handle/123456789/92 | |
| dc.description | Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+ | en_US |
| dc.description.abstract | Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+ | en_US |
| dc.format | application/pdf | |
| dc.language.iso | eng | en_US |
| dc.rights | Info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Bacillus | en_US |
| dc.subject | surfactins | en_US |
| dc.subject | pumilacidins | en_US |
| dc.subject | coral-associated bacteria | en_US |
| dc.subject | P. falciparum | en_US |
| dc.subject | apoptosis | en_US |
| dc.title | Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum | en_US |
| dc.type | info:eu-repo/semantics/article | en_US |
| dc.type | Info:eu-repo/semantics/publishedversion | |
