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dc.contributor.authorAmmulu, Manne Anupama
dc.contributor.authorRosaiah, Gorrepati
dc.contributor.authorManagmauri, Usha Kiranmayi
dc.contributor.authorVemuri, Praveen Kumar
dc.contributor.authorRao, KRS
dc.contributor.authorSudhakar, P
dc.date.accessioned2020-06-18T19:49:57Z
dc.date.available2020-06-18T19:49:57Z
dc.date.issued2017-10-01
dc.identifier.issn0973-8916
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/96
dc.descriptionL-asparaginase (L-asparagine amino hydrolase) is an enzyme which was clinically proved as an antitumor agent to treat acute lymphoblastic leukemia. It catalyzes L-asparagine hydrolysis to L-aspartate and ammonia, and the depletion of asparagine causes cytotoxicity to leukemic cells. Microbial L-asparaginase (ASNase) production has attracted good attention regarding its cost effectiveness and ecofriendliness. The focus of this review is to provide a discussion regarding the microbial ASNase production, purification, its mechanism of action, sources, therapeutic side effects and focusing on the future prospects like protein engineering, recombinant microorganisms to develop a efficient therapeutics with significantly less side effects. This study is also focusing on the production of ASNases from new sources with improvement in the availability as a drug, and issues related to reducing the cost of the drug by improving the pharmacokinetics, pharmaco-dynamics and toxicological profiles in producing the ASNase enzyme.en_US
dc.description.abstractL-asparaginase (L-asparagine amino hydrolase) is an enzyme which was clinically proved as an antitumor agent to treat acute lymphoblastic leukemia. It catalyzes L-asparagine hydrolysis to L-aspartate and ammonia, and the depletion of asparagine causes cytotoxicity to leukemic cells. Microbial L-asparaginase (ASNase) production has attracted good attention regarding its cost effectiveness and ecofriendliness. The focus of this review is to provide a discussion regarding the microbial ASNase production, purification, its mechanism of action, sources, therapeutic side effects and focusing on the future prospects like protein engineering, recombinant microorganisms to develop a efficient therapeutics with significantly less side effects. This study is also focusing on the production of ASNases from new sources with improvement in the availability as a drug, and issues related to reducing the cost of the drug by improving the pharmacokinetics, pharmaco-dynamics and toxicological profiles in producing the ASNase enzyme.en_US
dc.language.isoenen_US
dc.subjectMicrobial L-asparaginase productionen_US
dc.subjectBiopharmaceutical drugen_US
dc.subjectAcute Lymphoblastic leukemiaen_US
dc.titleL-Asparaginase a Biotherapeutic for Acute Lymphoblastic Leukemia-A Molecular Perspectiveen_US
dc.typeArticleen_US


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