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dc.contributor.authorMartínez, Luis sergio
dc.contributor.authorGómez, José Félix
dc.contributor.authorSpadafora, Carmenza
dc.contributor.authorGuzmán, Héctor M.
dc.contributor.authorGutiérrez, Marcelino
dc.date.accessioned2020-06-19T05:25:20Z
dc.date.available2020-06-19T05:25:20Z
dc.date.issued2012-09-18
dc.identifier.issnISSN 1420-3049
dc.identifier.otherdoi:10.3390/molecules170911146
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/98
dc.descriptionFractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl--oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 1−5 were established by spectroscopic analyses, including HRESITOF-MS and NMR (1 H, 13C, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 1−5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.en_US
dc.description.abstractFractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl--oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 1−5 were established by spectroscopic analyses, including HRESITOF-MS and NMR (1 H, 13C, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 1−5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.en_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectindole alkaloidsen_US
dc.subjectTrypanosoma cruzien_US
dc.subjectBacillus pumilusen_US
dc.subjectChagas diseaseen_US
dc.titleAntitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilusen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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