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Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama

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Paromomycin-Gentamicine-Phase-II-AJTMH-Sept 2013-557.full-17.pdf (408.9Kb)
Date
2013-07-15
Author
Sosa, Nestor
Capitan, Zeuz
Nieto, Javier
Nieto, Melissa
Calzada, Jose
Paz, Hector
Spadafora, Carmenza
Kreishman-Deitrick, Mara
Kopydlowski, Karen
Ullman, Diane
McCarthy, William F.
Ransom, Janet
Berman, Jonathan
Scott, Charles
Grogl, Max
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Abstract
In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% gentamicin) or Paromomycin Alone (15% paromomycin) for 20 days. The index lesion cure rate after 6 months follow-up was 13 of 15 (87%) for WR 279,396 and 9 of 15 (60%) for Paromomycin Alone (P = 0.099). When all treated lesions were included, the final cure rate for WR 279,398-treated patients was again 87%, but the final cure rate for Paromomycin Alone-treated patients was 8 of 15 (53.3%; P = 0.046). Both creams were well tolerated with mild application site reactions being the most frequent adverse event. The increased final cure rate in the WR 279,396 group in this small Phase 2 study suggests that the combination product may provide greater clinical benefit than paromomycin monotherapy against L. panamensis cutaneous leishmaniasis
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http://repositorio-indicasat.org.pa/handle/123456789/100
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El enlace del OAI de este repositorio: www.repositorio-indicasat.org.pa/oai/request
Repositorio del Instituto de Investigaciones Científicas y Servicios de Alta Tecnología de Panamá (INDICASAT).
Utiliza DSpace copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback