| dc.contributor.author | Fenner, Amanda M. | |
| dc.contributor.author | Engene, Niclas | |
| dc.contributor.author | Spadafora, Carmenza | |
| dc.contributor.author | Gerwick, William H. | |
| dc.contributor.author | Balunas, Marcy J. | |
| dc.date.accessioned | 2020-06-24T17:02:19Z | |
| dc.date.available | 2020-06-24T17:02:19Z | |
| dc.date.issued | 2016-01-19 | |
| dc.identifier.other | : 10.1021/acs.orglett.5b03110. | |
| dc.identifier.uri | http://repositorio-indicasat.org.pa/handle/123456789/107 | |
| dc.description | From a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully characterized. Medusamide A contains four contiguous β-amino acid (2R,3R)-3-amino-2-methylhexanoic acid (Amha) residues. This is the first report of multiple Amha residues and contiguous β-amino acid residues within a single cyclic peptide-type natural product. Stereochemical assignment of the Amha residues was completed following the synthesis of reference standards for this β-amino acid and the subsequent derivatization with Marfey’s reagent and LC−MS analysis. | en_US |
| dc.description.abstract | From a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully characterized. Medusamide A contains four contiguous β-amino acid (2R,3R)-3-amino-2-methylhexanoic acid (Amha) residues. This is the first report of multiple Amha residues and contiguous β-amino acid residues within a single cyclic peptide-type natural product. Stereochemical assignment of the Amha residues was completed following the synthesis of reference standards for this β-amino acid and the subsequent derivatization with Marfey’s reagent and LC−MS analysis. | en_US |
| dc.format | application/pdf | |
| dc.language.iso | eng | en_US |
| dc.rights | Info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Panamanian Cyanobacterial | en_US |
| dc.subject | Depsipeptide with Multiple | en_US |
| dc.subject | ‑Amino Acids | en_US |
| dc.title | Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β‑Amino Acids | en_US |
| dc.type | info:eu-repo/semantics/article | en_US |
| dc.type | Info:eu-repo/semantics/publishedversion | |
