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dc.contributor.authorGovindaraju, M
dc.contributor.authorJayanth, KS Rao
dc.contributor.authorKumar, D Jagadeesh
dc.contributor.authorRao, UJS Prasada
dc.contributor.authorRao, KRS Sambasiva
dc.contributor.authorRao, KS
dc.date.accessioned2020-06-25T01:52:48Z
dc.date.available2020-06-25T01:52:48Z
dc.date.issued2017-01-01
dc.identifier.other10.3233/ADR-170027
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/110
dc.descriptionDNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are the etiological factors for neurodegenerative diseases and hypothesized that they can cause DNA instability. In the current investigation, we studied copper and Aβ1-16 induced conformation and stability changes in CAG/CTG sequences and found alterations from B-DNA to altered B-conformation. Further, the interaction of the copper and Aβ1-16 with CAG/CTG sequences was studied by molecular docking modeling and results indicated that the interaction of copper and Aβ1-16 was through the hydrogen bond formation between adenine, guanine, and cytocine. This study illustrates the role of the copper and Aβ1-16 in modulating the DNA conformation and stability.en_US
dc.description.abstractDNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are the etiological factors for neurodegenerative diseases and hypothesized that they can cause DNA instability. In the current investigation, we studied copper and Aβ1-16 induced conformation and stability changes in CAG/CTG sequences and found alterations from B-DNA to altered B-conformation. Further, the interaction of the copper and Aβ1-16 with CAG/CTG sequences was studied by molecular docking modeling and results indicated that the interaction of copper and Aβ1-16 was through the hydrogen bond formation between adenine, guanine, and cytocine. This study illustrates the role of the copper and Aβ1-16 in modulating the DNA conformation and stability.en_US
dc.language.isoenen_US
dc.subjectCircular dichroismen_US
dc.subjectconformationen_US
dc.subjectneurodegenerationen_US
dc.subjecttrinucleotidesen_US
dc.titleStudies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequenceen_US
dc.typeArticleen_US


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