• English
    • español
  • English 
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • Investigación
  • Artículos Científicos
  • View Item
  •   DSpace Home
  • Investigación
  • Artículos Científicos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Studies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence

Thumbnail
View/Open
Artículo Principal (1.141Mb)
Date
2017-01-01
Author
Govindaraju, M
Jayanth, KS Rao
Kumar, D Jagadeesh
Rao, UJS Prasada
Rao, KRS Sambasiva
Rao, KS
Metadata
Show full item record
Abstract
DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are the etiological factors for neurodegenerative diseases and hypothesized that they can cause DNA instability. In the current investigation, we studied copper and Aβ1-16 induced conformation and stability changes in CAG/CTG sequences and found alterations from B-DNA to altered B-conformation. Further, the interaction of the copper and Aβ1-16 with CAG/CTG sequences was studied by molecular docking modeling and results indicated that the interaction of copper and Aβ1-16 was through the hydrogen bond formation between adenine, guanine, and cytocine. This study illustrates the role of the copper and Aβ1-16 in modulating the DNA conformation and stability.
URI
http://repositorio-indicasat.org.pa/handle/123456789/110
Collections
  • Artículos Científicos

El enlace del OAI de este repositorio: www.repositorio-indicasat.org.pa/oai/request
Repositorio del Instituto de Investigaciones Científicas y Servicios de Alta Tecnología de Panamá (INDICASAT).
Utiliza DSpace copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback

 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

LoginRegister

Statistics

View Usage Statistics

El enlace del OAI de este repositorio: www.repositorio-indicasat.org.pa/oai/request
Repositorio del Instituto de Investigaciones Científicas y Servicios de Alta Tecnología de Panamá (INDICASAT).
Utiliza DSpace copyright © 2002-2016  DuraSpace
Contact Us | Send Feedback