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dc.contributor.authorMitra, Joy
dc.contributor.authorVasquez, Velmarini
dc.contributor.authorHegde, Pavana M.
dc.contributor.authorBoldogh, Istvan
dc.contributor.authorMitra, Sankar
dc.contributor.authorKent, Thomas A.
dc.contributor.authorRao, KS Jagannatha
dc.contributor.authorHegde, Muralidhar L
dc.date.accessioned2020-07-03T22:08:11Z
dc.date.available2020-07-03T22:08:11Z
dc.date.issued2015-01-23
dc.identifier.other10.14437/NRTOA-1-107
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/170
dc.descriptionExcessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasis-mediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.en_US
dc.description.abstractExcessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasis-mediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.en_US
dc.language.isoenen_US
dc.subjectMetal Toxicityen_US
dc.subjectNeurodegenerative Diseasesen_US
dc.subjectStrokeen_US
dc.subjectTherapeutic Potentialen_US
dc.titleRevisiting metal toxicity in neurodegenerative diseases and stroke: Therapeutic potential.en_US
dc.typeArticleen_US


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