Mostrar el registro sencillo del ítem

dc.contributor.authorGovindaraju, M
dc.contributor.authorShekar, HS
dc.contributor.authorSateesha, SB
dc.contributor.authorVasudeva Raju, P
dc.contributor.authorRao, KR Sambasiva
dc.contributor.authorRao, KS Jagannatha
dc.contributor.authorRajamma, AJ
dc.date.accessioned2020-07-03T22:50:17Z
dc.date.available2020-07-03T22:50:17Z
dc.date.issued2013-10-01
dc.identifier.other10.1016/j.jpha.2013.03.003
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/171
dc.descriptionIn this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2+ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer's disease and other neurological disorders.en_US
dc.description.abstractIn this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2+ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer's disease and other neurological disorders.en_US
dc.language.isoenen_US
dc.subjectHuman brainen_US
dc.subjectChromatinen_US
dc.subjectDNAen_US
dc.subjectCopperen_US
dc.subjectNeurodegenerative disordersen_US
dc.titleCopper interactions with DNA of chromatin and its rolein neurodegenerative disorders.en_US
dc.typeArticleen_US


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem