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dc.contributor.authorGittens, Rolando A.
dc.contributor.authorOlivares-Navarrete, Rene
dc.contributor.authorRettew, Robert
dc.contributor.authorButera, Robert J.
dc.contributor.authorAlamgir, Faisal M.
dc.contributor.authorBoyan, Barbara D.
dc.contributor.authorSchwartz, Zvi
dc.date.accessioned2020-08-08T17:48:19Z
dc.date.available2020-08-08T17:48:19Z
dc.date.issued2013-08-29
dc.identifier.otherdoi.org/10.1002/bem.21810
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/229
dc.descriptionElectrical stimulation has been used clinically to promote bone regeneration in cases of fractures with delayed union or nonunion, with several in vitro and in vivo reports suggesting its beneficial effects on bone formation. However, the use of electrical stimulation of titanium (Ti) implants to enhance osseointegration is less understood, in part because of the few in vitro models that attempt to represent the in vivo environment. In this article, the design of a new in vitro system that allows direct electrical stimulation of osteoblasts through their Ti substrates without the flow of exogenous currents through the media is presented, and the effect of applied electrical polarization on osteoblast differentiation and local factor production was evaluated. A custom-made polycarbonate tissue culture plate was designed to allow electrical connections directly underneath Ti disks placed inside the wells, which were supplied with electrical polarization ranging from 100 to 500 mV to stimulate MG63 osteoblasts. Our results show that electrical polarization applied directly through Ti substrates on which the cells are growing in the absence of applied electrical currents may increase osteoblast differentiation and local factor production in a voltage-dependent manner. Bioelectromagnetics © 2013 Wiley Periodicals, Incen_US
dc.description.abstractElectrical stimulation has been used clinically to promote bone regeneration in cases of fractures with delayed union or nonunion, with several in vitro and in vivo reports suggesting its beneficial effects on bone formation. However, the use of electrical stimulation of titanium (Ti) implants to enhance osseointegration is less understood, in part because of the few in vitro models that attempt to represent the in vivo environment. In this article, the design of a new in vitro system that allows direct electrical stimulation of osteoblasts through their Ti substrates without the flow of exogenous currents through the media is presented, and the effect of applied electrical polarization on osteoblast differentiation and local factor production was evaluated. A custom-made polycarbonate tissue culture plate was designed to allow electrical connections directly underneath Ti disks placed inside the wells, which were supplied with electrical polarization ranging from 100 to 500 mV to stimulate MG63 osteoblasts. Our results show that electrical polarization applied directly through Ti substrates on which the cells are growing in the absence of applied electrical currents may increase osteoblast differentiation and local factor production in a voltage-dependent manner. Bioelectromagnetics © 2013 Wiley Periodicals, Incen_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectelectrical stimulationen_US
dc.subjectcurrenten_US
dc.subjectosseointegration of metalen_US
dc.subjectimplantsen_US
dc.subjectboneen_US
dc.subjectTi surface propertiesen_US
dc.subjectpolarizationen_US
dc.titleElectrical Polarization of Titanium Surfacesfor the Enhancement of Osteoblast Differentiationen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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