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dc.contributor.authorMitra, Joy
dc.contributor.authorVasquez, Velmarini
dc.contributor.authorHegde, Pavana M
dc.contributor.authorBoldogh, Istvan
dc.contributor.authorMitra, Sankar
dc.contributor.authorKent, Thomas A
dc.contributor.authorRao, Kosagi S
dc.contributor.authorL Hegde, Muralidhar
dc.date.accessioned2020-08-19T22:45:12Z
dc.date.available2020-08-19T22:45:12Z
dc.date.issued2014-12-31
dc.identifier.otherhttp://dx.doi.org/10.14437/NRTOA-1-107
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/243
dc.descriptionExcessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasismediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.en_US
dc.description.abstractExcessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasismediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeurodegenerativeen_US
dc.subjectToxicityen_US
dc.subjecthomeostasisen_US
dc.titleRevisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potentialen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeinfo:edu-repo/semantics/publishedVersion


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