Buscar
Mostrando ítems 1-7 de 7
α-Synuclein misfolding versus aggregation relevance to Parkinson’s disease: Critical assessment and modeling
(2015-06-01)
α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in
Parkinson’s disease (PD). The aggregation of α-synuclein isbelieved to be a critical event in the isease process. ...
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
(2020-02-01)
α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ...
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson’s Disease
(2018-11-08)
Altered expression of α-synuclein is linked to Parkinson’s disease (PD). A major challenge to explore how the increased α-synuclein affect neurotoxicity is the lack of a suitable human neuronal cell model that mimics this ...
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease
(2019-09-01)
Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ...
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
(2019-03-05)
Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The ...
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson’s disease
(2017-01-01)
Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ...
Revisiting metal toxicity in neurodegenerative diseases and stroke: Therapeutic potential.
(2015-01-23)
Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as ...