Buscar
Mostrando ítems 1-10 de 25
Comparative study on anti-oxidant and anti-inflammatory activities of Caesalpinia crista and Centella asiatica leaf extracts
(2014-04-01)
Background:
Amyloidosis, oxidative stress and inflammation have been strongly implicated in neurodegenerative disorders like Alzheimer's disease. Traditionally, Caesalpinia crista and Centella asiatica leaf extracts are ...
In vitro evidence that an aqueous extract of Centella asiatica modulates α-synuclein aggregation dynamics.
(2014-01-01)
α-Synuclein aggregation is one of the major etiological factors implicated in Parkinson's disease (PD). The prevention of ggregation of α-synuclein is a potential therapeutic intervention for preventing PD. The discovery ...
The effects of impaired cerebral circulation on Alzheimer's disease pathology: evidence from animal studies.
(2014-01-01)
Persistent systemic hypoxia, a direct consequence of alterations in vascular function, can compromise the brain by
increasing the risk of developing dementias such as Alzheimer’s disease (AD). Vascular contributions to ...
α-Synuclein misfolding versus aggregation relevance to Parkinson’s disease: Critical assessment and modeling
(2015-06-01)
α-Synuclein, an abundant and conserved presynaptic brain protein, is implicated as a critical factor in
Parkinson’s disease (PD). The aggregation of α-synuclein isbelieved to be a critical event in the isease process. ...
Vacuolar Targeting of Cry1Ac and its Effects on Expression and Stability in Tobacco.
(2014-07-01)
Increasing heterologous expression of delta endotoxins of Bacillus thuringiensis in transgenic plants is being actively pursued as a
means to increase their efficacy and to delay insect resistance. To examine if vacuoles ...
Effect of Post Weld Heat Treatments on the Elevated Temperature Mechanical Properties of Ti6Al4V Friction Welds
(2018-02-09)
The {\alpha}+\b {eta} titanium alloy (Ti6Al4V) has been successfully joined using rotary friction welding. To investigate the influence of post weld heat treatments on the microstructure and mechanical properties of the ...
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
(2020-02-01)
α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) present in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) ...
A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods
(2014-10-11)
The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the ...
The lipid content and fatty acid composition of four eastern central Pacific native fish species
(2014-02-01)
Fish is an important source of nutritious n-3 fatty acids, which are necessary for the prevention of cardiovascular and neurological diseases. The lipid content and fatty acid composition of economically important fishes ...
Development of anthracycline-induced dilated cardiomyopathy due to mutation on LMNA gene in a breast cancer patient: a case report
(2019-07-16)
Background
Anthracyclines are highly effective anticancer medication prescribed for the treatment of breast cancer. Nevertheless, the use of anthracyclines as chemotherapeutic agents involves a risk for development of ...