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Cytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera. EmilyCytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera.
(2011-04-13)
A family of cancer cell cytotoxic cyclodepsipeptides, veraguamides A-C( 1-3) and H-L( 4-8), were isolated from a collection of cf. Oscillatoria margaritifera obtained from the Coiba National Park, Panama, as part of the ...
Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants
(2013-09-16)
Fungal endophytes – fungi that grow within plant tissues without causing immediate signs of disease – are abundant and diverse producers of bioactive secondary metabolites. Endophytes associated with leaves of tropical ...
Volatile organic compounds associated with Plasmodium falciparum infection in vitro
(2017-05-02)
Background: In order to identify new ways to prevent transmission of vector-borne diseases such as malaria, efforts have been made to understand how insects are attracted to humans. Vector-host interaction studies have ...
Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants
(2017-07-17)
The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved ...
Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
(2017-09-18)
Ten antifouling 14-membered resorcylic acid lactones 1–10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation conditions ...
Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice
(2016-11-01)
Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce. Objective—To identify novel cyanobacterial compounds that exhibit CNS psychoactive effects. ...
Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice
(2016-11-08)
Context—Marine cyanobacteria offer a robust resource for natural products drug discovery due to the secondary metabolites they produce.
Objective—To identify novel cyanobacterial compounds that exhibit CNS psychoactive ...
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
(2019-03-25)
Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has ...
Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice
(2020-03-09)
Plasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasite s resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments ...
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
(2012-09-18)
Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), ...