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Environmental Conditions May Shape the Patterns of Genomic Variations in Leishmania panamensis
(2019-10-24)
Due to the absence of transcriptional regulation of gene expression in Leishmania parasites, it is now well accepted that several forms of genomic variations modulate the levels of critical proteins through changes in gene ...
Chromatin-bound oxidized α-synuclein causes strand breaks in neuronal genomes in in vitro models of Parkinson's Disease
(2019-09-01)
Alpha-synuclein (α-Syn) overexpression and misfolding/aggregation in degenerating dopaminergic neurons have long been implicated in Parkinson’s disease (PD). The neurotoxicity of α-Syn is enhanced by iron (Fe) and other ...
The impact of biological invasion and genomic local adaptation on the geographical distribution of Aedes aegypti in Panama
(2019-01-01)
Local adaptation is an important consideration when predicting arthropod-borne disease risk because it can impact on vector population fitness and persistence. However, the extent that vector populations are adapted to ...
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects
(2019-03-05)
Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The ...
Avian Mycobacteriosis in a Rescued Harpy Eagle from Darien Forest, Panama
(2019-11-08)
Background: The Harpy eagle (Harpia harpyia) is the largest raptor in the Neotropical region, distributed in low densities within primary forest habitats from southern Mexico to east-central Brazil, including Central America ...
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro
(2019-03-25)
Even with access to sufficient nutrients and atmosphere, Plasmodium falciparum can barely be cultured at maximum growth capacity in vitro conditions. Because of this behavior, it has been suggested that P. falciparum has ...
Diverse novel phleboviruses in sandflies from the Panama Canal area, Central Panama
(2019-05-03)
The genus Phlebovirus (order Bunyavirales, family Phenuiviridae) comprises 57 viruses that are grouped into nine speciescomplexes. Sandfly-transmitted phleboviruses are found in Europe, Africa and the Americas and are ...
Avian Mycobacteriosis in a Rescued Harpy Eagle from Darien Forest, Panama
(Acta Scientiae Veterinariae, 2019-06-20)
The Harpy eagle (Harpia harpyia) is the largest raptor in the Neotropical region, distributed in low densities within primary forest habitats from southern Mexico to east-central Brazil, including Central America and ...
Detecting space-time clusters of dengue fever in Panama after adjusting for vector surveillance data
(2019-09-23)
Long term surveillance of vectors and arboviruses is an integral aspect of disease prevention and control systems in countries affected by increasing risk. Yet, little effort has been made to adjust space-time risk estimation ...
Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis
(2019-11-07)
Alzheimer’s disease (AD) is the most devastating neurodegenerative disorder that affects the aging population worldwide. Endogenous and exogenous factors are involved in triggering this complex and multifactorial disease, ...