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dc.contributor.authorTayler, Nicole M.
dc.contributor.authorDe Jesús, Rosa
dc.contributor.authorSpadafora, Rita
dc.contributor.authorCoronado, Lorena M.
dc.contributor.authorSpadafora, Carmenza
dc.date.accessioned2020-06-17T04:27:19Z
dc.date.available2020-06-17T04:27:19Z
dc.date.issued2020-03-09
dc.identifier.issnISSN 0971-7196
dc.identifier.otherdoi.org/10.1007/s12639-020-01207-7
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/85
dc.descriptionPlasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasites resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments against the disease. For this reason, the study of natural products to find new antimalarials remains a crucial step in the fight against malaria. In this study, we aimed to study the in vivo performance of the decoction of C. nucifera leaves in P. berghei-infected mice. We analyzed the effectiveness of different routes of administration and the acute toxicity of the extract. Additionally, we determined the suppressive, curative and prophylactic activity of the extract. The results showed that the decoction of leaves of C. nucifera is most effective when administered intramuscularly to mice in comparison to intraperitoneal, subcutaneous and intragastric methods. We also found that organ signs of acute toxicity appear at 2000 mg/kg/day as evidenced by necropsy examination. Additionally, we found that the prophylactic effect of the extract is of 48% inhibition, however, there is no curative effect. Finally, in a 4-day suppressive assay, we found that the extract can inhibit the growth of the parasite by up to 54% at sub-toxic doses when administered intramuscularlyen_US
dc.description.abstractPlasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasites resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments against the disease. For this reason, the study of natural products to find new antimalarials remains a crucial step in the fight against malaria. In this study, we aimed to study the in vivo performance of the decoction of C. nucifera leaves in P. berghei-infected mice. We analyzed the effectiveness of different routes of administration and the acute toxicity of the extract. Additionally, we determined the suppressive, curative and prophylactic activity of the extract. The results showed that the decoction of leaves of C. nucifera is most effective when administered intramuscularly to mice in comparison to intraperitoneal, subcutaneous and intragastric methods. We also found that organ signs of acute toxicity appear at 2000 mg/kg/day as evidenced by necropsy examination. Additionally, we found that the prophylactic effect of the extract is of 48% inhibition, however, there is no curative effect. Finally, in a 4-day suppressive assay, we found that the extract can inhibit the growth of the parasite by up to 54% at sub-toxic doses when administered intramuscularlyen_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectPlasmodium falciparumen_US
dc.subjectCocos nucifera Aqueous extracten_US
dc.subjectAntiplasmodial Plasmodium bergheien_US
dc.titleAntiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected miceen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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