Browsing by Title

Now showing items 179-198 of 227

    • Proteomic fingerprint identification of Neotropical hard tick species (Acari: Ixodidae) using a self-curated mass spectra reference library 

      Gittens, Rolando A.; Almanza, Alejandro; Álvarez, Eric; Bennett, Kelly L.; Mejía, Luis C.; Sanchez-Galan, Javier E.; Merchan, Fernando; Kern, Jonathan; Miller, Matthew J.; Esser, Helen J.; Hwang, Robert; Dong, May; De León, Luis F.; Loaiza, Jose R. (2020-04-14)
      Matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry is an analytical method that detects macromolecules that can be used as biomarkers for taxonomic identification in arthropods. The ...

    • A Pseudopterane Diterpene Isolated From the Octocoral Pseudopterogorgia acerosa Inhibits the Inflammatory Response Mediated by TLR-Ligands and TNF-Alpha in Macrophages 

      González, Yisett; Doens, Deborah; Santamaría, Ricardo; Ramos, Marla; Restrepo, Carlos M.; Barros de Arruda, Luciana; Lleonart, Ricardo; Gutiérrez, Marcelino; Fernández, Patricia L. (2013-12-16)
      Several diterpenoids isolated from terrestrial and marine environments have been identified as important anti-inflammatory agents. Although considerable progress has been made in the area of anti-inflammatory treatment, ...

    • Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum 

      Torres-Mendoza, Daniel; Coronado, Lorena M.; Pineda, Laura M.; Guzmán, Héctor M.; Dorrestein, Pieter C.; Spadafora, Carmenza; Gutiérrez, Marcelino (2018-08-29)
      Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum ...

    • Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama 

      Sosa, Nestor; Capitan, Zeus; Nieto, Javier; Nieto, Melissa; Calzada, Jose; Paz, Hector; Spadafora, Carmenza; Kreishman, Mara Deitric; Kopydlowski, Karen; Ullman, Diane; McCarthy, William F.; Ransom, Janet; Berman, Jhonathan; Scott, Charles; Grogl, Max (2013-07-15)
      In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ...

    • Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama 

      Sosa, Nestor; Capitan, Zeuz; Nieto, Javier; Nieto, Melissa; Calzada, Jose; Paz, Hector; Spadafora, Carmenza; Kreishman-Deitrick, Mara; Kopydlowski, Karen; Ullman, Diane; McCarthy, William F.; Ransom, Janet; Berman, Jonathan; Scott, Charles; Grogl, Max (2013-07-15)
      In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ...

    • Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama 

      Sosa, Nestor; Capitan, Zeus; Nieto, Javier; Nieto, Melissa; Calzada, Jose; Paz, Hector; Spadafora, Carmenza; Kreishman, Mara Deitric; Kopydlowski, Karen; Ullman, Diane; McCarthy, William F.; Ransom, Janet; Berman, Jonathan; Scott, Charles; Grogl, Max (2013-07-15)
      In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ...

    • Recommendations of generic names in Diaporthales competing for protection or use. 

      Rossman, AY.; Adams, GC.; Cannon, PF.; Castlebury, LA.; Crous, PW.; Gryzenhout, M.; Jaklitsch, WM.; Mejía, Luis Carlos; Stoykov, D.; Udayanga, D.; Voglmayr, H.; Walker, DM. (2015-06-04)
      In advancing to one name for fungi, this paper treats generic names competing for use in the order Diaporthales (Ascomycota, Sordariomycetes) and makes a recommendation for the use or protection of one generic name among ...

    • Reduced Food Intake Among Tuberculosis Patients Within an Urban Setting in Panama (P10-023-19) 

      Cubilla, Idalina; Rios, Maritza; Batista, Victoria; Rosero, Sara; Sambrano, Dilcia; Castillo, Juan; Colon-Ramos, Uriyoan; Cleary, Sean D; Goodridge, Amador; Luque, Odemaris; de Simmons, Isolina; de Chavez, Ana; Cuadra, Yaracelys; Jurado, Julio; Gonzalez, Rolando; Williams, Victoria (2019-06-01)
      Objectives The aim of our study is to characterize the dietary factors and food items intake of people living with pulmonary tuberculosis in an urban and high disease incidence city in Panama. Methods We recruited 41 ...

    • Regulating in vivo calcification of alginate microbeads 

      S.D. Lee, Christopher; Moyer, Hunter R.; Gittens I, Rolando A.; Williams, Joseph K.; Boskey, Adele L.; Boyan, Barbara D.; Schwartz, Zvi (2010-04-02)
      Alginate calcification has been previously reported clinically and during animal implantation; however no study has investigated the mechanism, extensively characterized the mineral, or evaluated multiple methods to regulate ...

    • Relación entre las funciones ejecutivas y el rendimiento académico en una muestra de escolares 

      Flores, Julio; Pérez, Ambar; Oviedo, Diana; Britton, Gabrielle B; Mojica, Marita (2020-07-30)
      En la última década, la integración entre las neurociencias y la educación hacontribuido a la comprensión y mejoramiento del sistema educativo, además, se ha mostrado un interés en el estudio de las funciones ejecutivas y ...

    • A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods 

      Madrigal, Marialaura; Rao, KS Jagannatha; Riordan, Neil H (2014-10-11)
      The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the ...

    • A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods 

      Madrigal, Marialaura; S Rao, Kosagisharaf; H. Riordan, Neil (Madrigal et al. Journal of Translational Medicine, 2014-10-11)
      The mesenchymal stem cell (MSC) is being broadly studied in clinical trials. Contrary to the early paradigm of cell replacement and differentiation as a therapeutic mechanism of action, evidence is mounting that the ...

    • A review on the wettability of dental implant surfaces I: Theoretical and experimental aspects 

      Rupp, Frank; Gittens, Rolando A.; Scheideler, Lutz; Marmur, Abraham; Boyan, Barbara D.; Schwartz, Zvi; Geis-Gerstorfer, Jürgen (2014-02-28)
      The surface wettability of biomaterials determines the biological cascade of events at the biomaterial/ host interface. Wettability is modulated by surface characteristics, such as surface chemistry and surface topography. ...

    • A review on the wettability of dental implant surfaces II: Biological and clinical aspects 

      Gittens, Rolando A.; Scheideler, Lutz; Rupp, Frank; Hyzy, Sharon L.; Geis-Gerstorfer, Jürgen; Schwartz, Zvi; Boyan, Barbara D. (2014-04-05)
      Dental and orthopedic implants have been under continuous advancement to improve their interactions with bone and ensure a successful outcome for patients. Surface characteristics such as surface topography and surface ...

    • Revisión de Modelos Hiperelásticos utilizados en Tejidos 

      Moreno, Miguel; Plazaola, Carlos; González, Guadalupe; Zambrano, Mayteé; Spadafora, Carmenza (2018-02-04)
      This work is related to the hyperelastic models most used in soft tissue. The importance of obtaining accurate mechanical properties of tissues are of great interest for various medical applications, for example: in treatment ...

    • Revisión de Modelos Hiperelásticos utilizados en Tejidos 

      Moreno, Miguel; Plazaola, Carlos; González, Guadalupe; Zambrano, Mayteé; Spadafora, Carmenza (2018-02-04)
      This work is related to the hyperelastic models most used in soft tissue. The importance of obtaining accurate mechanical properties of tissues are of great interest for various medical applications, for example: in treatment ...

    • Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential 

      Mitra, Joy; Vasquez, Velmarini; Hegde, Pavana M; Boldogh, Istvan; Mitra, Sankar; Kent, Thomas A; Rao, Kosagi S; L Hegde, Muralidhar (2014-12-31)
      Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as ...

    • Revisiting metal toxicity in neurodegenerative diseases and stroke: Therapeutic potential. 

      Mitra, Joy; Vasquez, Velmarini; Hegde, Pavana M.; Boldogh, Istvan; Mitra, Sankar; Kent, Thomas A.; Rao, KS Jagannatha; Hegde, Muralidhar L (2015-01-23)
      Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a ontributor to the brain pathology including neurodegenerative diseases and acute injuries such as ...

    • Role of a2b1 integrins in mediating cell shape on microtextured titanium surfaces 

      Lai, Min; Hermann, Christopher D.; Cheng, Alice; Olivares-Navarrete, Rene; Gittens, Rolando A.; Bird, Meredith M.; Walker, Marcus; Cai, Ye; Cai, Kaiyong; Sandhage, Kenneth H.; Schwartz, Zvi; Boyan, Barbara D. (2014-05-07)
      Surface microroughness plays an important role in determining osteoblast behavior on titanium. Previous studies have shown that osteoblast differentiation on microtextured titanium substrates is dependent on alpha-2 beta-1 ...

    • Rough titanium alloys regulate osteoblast production of angiogenic factors 

      Olivares-Navarrete, Rene; DDS; PhD; Hyzy, Sharon L.; MS; Gittens, Rolando A.; I, I; Schneider, Jennifer M.; MS; Haithcock, David A.; BS, BS; Ullrich, Peter F.; Slosar, Paul J.; MD, MD; Schwartz, Zvi; DMD; PhD; Boyan, Barbara D.; PhD (2013-05-14)
      Multiple biomaterials are clinically available to spine surgeons for performing interbody fusion. Poly-ether-ether-ketone (PEEK) is used frequently for lumbar spine interbody fusion, but alternative materials are also used, ...