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dc.contributor.authorFenner, Amanda M.
dc.contributor.authorEngene, Niclas
dc.contributor.authorSpadafora, Carmenza
dc.contributor.authorGerwick, William H.
dc.contributor.authorBalunas, Marcy J.
dc.date.accessioned2020-06-24T17:02:19Z
dc.date.available2020-06-24T17:02:19Z
dc.date.issued2016-01-19
dc.identifier.other: 10.1021/acs.orglett.5b03110.
dc.identifier.urihttp://repositorio-indicasat.org.pa/handle/123456789/107
dc.descriptionFrom a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully characterized. Medusamide A contains four contiguous β-amino acid (2R,3R)-3-amino-2-methylhexanoic acid (Amha) residues. This is the first report of multiple Amha residues and contiguous β-amino acid residues within a single cyclic peptide-type natural product. Stereochemical assignment of the Amha residues was completed following the synthesis of reference standards for this β-amino acid and the subsequent derivatization with Marfey’s reagent and LC−MS analysis.en_US
dc.description.abstractFrom a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully characterized. Medusamide A contains four contiguous β-amino acid (2R,3R)-3-amino-2-methylhexanoic acid (Amha) residues. This is the first report of multiple Amha residues and contiguous β-amino acid residues within a single cyclic peptide-type natural product. Stereochemical assignment of the Amha residues was completed following the synthesis of reference standards for this β-amino acid and the subsequent derivatization with Marfey’s reagent and LC−MS analysis.en_US
dc.formatapplication/pdf
dc.language.isoengen_US
dc.rightsInfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectPanamanian Cyanobacterialen_US
dc.subjectDepsipeptide with Multipleen_US
dc.subject‑Amino Acidsen_US
dc.titleMedusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β‑Amino Acidsen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeInfo:eu-repo/semantics/publishedversion


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