Investigación: Recent submissions
Now showing items 141-160 of 227
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Phytochemical composition, antiparasitic and α–glucosidase inhibition activities from Pelliciera rhizophorae
(2015-09-28)Panama has an extensive mangrove area and it is one of the countries with the highest biodiversity in America. Mangroves are widely used in traditional medicine, nevertheless, there are very few studies that validates their ... -
Blood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields
(2016-08-18)The development of resistance to insecticides by the vector of malaria and the increasingly faster appearance of resistance to antimalarial drugs by the parasite can dangerously hamper efforts to control and eradicate the ... -
Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β‑Amino Acids
(2016-01-19)From a collection of marine cyanobacteria made in the Coiba National Park along the Pacific coast of the Republic of Panama a novel cyclic depsipeptide, given the trivial name medusamide A, has been isolated and fully ... -
Malarial hemozoin: From target to tool
(2014-02-17)Malaria is an extremely devastating disease that continues to affect millions of people each year. A distinctive attribute of malaria infected red blood cells is the presence of malarial pigment or the so-called hemozoin. ... -
Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass
(2014-03-04)In screening for natural products with antiparasitic activity, an endophytic fungus, strain F2611, isolated from above-ground tissue of the tropical grass Paspalum conjugatum (Poaceae) in Panama, was chosen for bioactive ... -
Sloth Hair as a Novel Source of Fungi with Potent AntiParasitic, Anti-Cancer and Anti-Bacterial Bioactivity
(2014-01-15)The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial ... -
Anti-malarial activity and HS-SPME-GC-MS chemical profiling of Plinia cerrocampanensis leaf essential oil
(2014-01-13)Plinia cerrocampanensis is an endemic plant of Panama. The leaf essential oil of this plant has shown antibacterial activity. However, anti-malarial activity and chemical profiling by HS-SPME-GC-MS of this essential oil ... -
Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants
(2013-09-16)Fungal endophytes – fungi that grow within plant tissues without causing immediate signs of disease – are abundant and diverse producers of bioactive secondary metabolites. Endophytes associated with leaves of tropical ... -
Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama
(2013-07-15)In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ... -
Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means
(2013-02-20)Unlike other Plasmodium species, P. falciparum can be cultured in the lab, which facilitates its study 1 . While the parasitemia achieved can reach the ≈40% limit, the investigator usually keeps the percentage at around ... -
Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
(2012-09-18)Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), ... -
Green Synthesis of Silver Nanoparticles using two Apocyanaceae plants and Screening for their Catalytic activity
(2017-07-27)The catalytic activity of biosynthesized silver nanoparticles (AgNPs) gained an importance in removal of synthetic dyes from waste water released form textile industries. In this study aqueous leaf extract of Cascabela ... -
L-Asparaginase a Biotherapeutic for Acute Lymphoblastic Leukemia-A Molecular Perspective
(2017-10-01)L-asparaginase (L-asparagine amino hydrolase) is an enzyme which was clinically proved as an antitumor agent to treat acute lymphoblastic leukemia. It catalyzes L-asparagine hydrolysis to L-aspartate and ammonia, and the ... -
Comparative study between open and laparoscopic ventral hernia repair: A prospective non-randomized single institutional study
(2017-10-01)Introduction: In this modern era of surgery, laparoscopic surgery has gained paramount importance. There is continued debate on the role of laparoscopy in ventral hernia repair. Although laparoscopic repair has become ... -
Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders
(2017-12-08)As neuroscientists, we were intrigued when Huang et al. (1) reported that miR101 can attenuate pulmonary fibrosis (PF)2 through suppression of Wnt family member 5A (WNT5A). Accumulating evidence suggests that prima facie ... -
An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson’s Disease
(2018-11-08)Altered expression of α-synuclein is linked to Parkinson’s disease (PD). A major challenge to explore how the increased α-synuclein affect neurotoxicity is the lack of a suitable human neuronal cell model that mimics this ... -
Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum
(2018-08-29)Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum ... -
Revisión de Modelos Hiperelásticos utilizados en Tejidos
(2018-02-04)This work is related to the hyperelastic models most used in soft tissue. The importance of obtaining accurate mechanical properties of tissues are of great interest for various medical applications, for example: in treatment ... -
Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian mangrove plants
(2018-01-02)To investigate 33 organic extracts of mangrove plants for: antiparasitic, anticancer, and antibacterial activities, as well as their ability to inhibit the activity of the 毩-glucosidase enzyme. Methods: Leaves from all ... -
Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
(2017-09-18)Ten antifouling 14-membered resorcylic acid lactones 1–10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation conditions ...