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Sloth Hair as a Novel Source of Fungi with Potent AntiParasitic, Anti-Cancer and Anti-Bacterial Bioactivity
(2014-01-15)
The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial ...
Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama
(2013-07-15)
In this randomized, double-blinded Phase 2 trial, 30 patients with Leishmania panamensis cutaneous leishmaniasis were randomly allocated (1:1) to receive once daily topical treatment with WR 279,396 (15% paromomycin + 0.5% ...
Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa
(2019-01-01)
Fractionation of the ethyl acetate extract of the bacterium Pseudomonas aeruginosa led to the isolation of five compounds, cyclo –(L-Phe-L-Pro) (1), 3-heptyl-3-hydroxy-1,2,3,4-tetrahydroquinoline-2.4-dione (2), ...
Sloth Hair as a Novel Source of Fungi with Potent AntiParasitic, Anti-Cancer and Anti-Bacterial Bioactivity
(2014-01-15)
The extraordinary biological diversity of tropical forests harbors a rich chemical diversity with enormous potential as a source of novel bioactive compounds. Of particular interest are new environments for microbial ...
Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice
(2020-03-09)
Plasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasites resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments ...
Bioactivity of Fungal Endophytes as a Function of Endophyte Taxonomy and the Taxonomy and Distribution of Their Host Plants
(2013-09-16)
Fungal endophytes – fungi that grow within plant tissues without causing immediate signs of disease – are abundant and diverse producers of bioactive secondary metabolites. Endophytes associated with leaves of tropical ...
Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes
(2011-05-18)
AmajorityofPlasmodiumfalciparumstrainsinvadeerythrocytesthroughinteractionswithsialicacid(SA) on glycophorins. However, we recently reported that complement receptor 1 (CR1) is a SA-independent invasionreceptorofmanylabo ...
Blood Stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields
(2016-08-18)
The development of resistance to insecticides by the vector of malaria and the increasingly faster appearance of resistance to antimalarial drugs by the parasite can dangerously hamper efforts to control and eradicate the ...
Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov.
(2011-12-12)
Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing ...
Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi
(2011-03-30)
Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic ...